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As both H 2 O 2 and BCNU exposure led to excessive cellular GSSG accumulation, their impact on intracellular protein-GSSG adduct formation (protein S -glutathionylation) was subsequently examined in HepG2 cells by western blot analysis using a monoclonal GSSG antibody that specifically binds to GSSG-modified proteins

doi: 10.1038/cdd.2011.92 51 FuhrmannDCMondorfABeifuJJungMBrneB

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The oral route avoids injection risks entirely, which is a genuine safety advantage for many users, though it shares the broader uncertainty about long-term effects